Tradeoff analysis of the pork supply and food security under the influence of African swine fever and the COVID-19 outbreak in China

China is the world's largest consumer of pork and grains. However, African swine fever (ASF) and the COVID-19 outbreak have greatly impacted the pork supply and food security in China. How can food security and the pork supply be ensured under the dual impacts of COVID-19 and ASF? This is a major problem to be urgently solved by the Chinese government. This study indicated that the main pork production and sales areas in China were separated, which reflected the spatial imbalance between the supply and demand. The total area of suitable selected sites for pig farms in China is 21.5 million ha. If only the areas with levels of high and moderate suitability are considered as potential sites for pig farms, the potential pork production can reach 56.1 million tons in China, which is slightly lower than demand. Due to the impact of the ASF epidemic, the food consumed by pigs has been reduced by 34.7 million tons. However, with increasing pork productivity in the future, the self-sufficiency rate of grains may further decline. On the premise that the quality of people's life is not affected, the diversification of meat supply channels should be realized in an orderly and sustainable way, which might alleviate the pressure on food supply. This study provides a theoretical reference for the spatiotemporal layout of the swine industry and addresses the issue of food security in China under the influence of ASF and the COVID-19 outbreak.

Immunomodulatory Mechanisms of Mesenchymal Stem Cells and Their Potential Clinical Applications.

Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal, homing, and low immunogenicity. These distinct biological characteristics have already shown immense potential in regenerative medicine. MSCs also possess immunomodulatory properties that can maintain immune homeostasis when the immune response is over-activated or under-activated. The secretome of MSCs consists of cytokines, chemokines, signaling molecules, and growth factors, which effectively contribute to the regulation of immune and inflammatory responses. The immunomodulatory effects of MSCs can also be achieved through direct cell contact with microenvironmental factors and immune cells. Furthermore, preconditioned and engineered MSCs can specifically improve the immunomodulation effects in diverse clinical applications. These multifunctional properties of MSCs enable them to be used as a prospective therapeutic strategy to treat immune disorders, including autoimmune diseases and incurable inflammatory diseases. Here we review the recent exploration of immunomodulatory mechanisms of MSCs and briefly discuss the promotion of the genetically engineered MSCs. Additionally, we review the potential clinical applications of MSC-mediated immunomodulation in four types of immune diseases, including systemic lupus erythematosus, Crohn's disease, graft-versus-host disease, and COVID-19.

Tradeoff analysis of the pork supply and food security under the influence of African swine fever and the COVID-19 outbreak in China

China is the world's largest consumer of pork and grains. However, African swine fever (ASF) and the COVID-19 outbreak have greatly impacted the pork supply and food security in China. How can food security and the pork supply be ensured under the dual impacts of COVID-19 and ASF? This is a major problem to be urgently solved by the Chinese government. This study indicated that the main pork production and sales areas in China were separated, which reflected the spatial imbalance between the supply and demand. The total area of suitable selected sites for pig farms in China is 21.5 million ha. If only the areas with levels of high and moderate suitability are considered as potential sites for pig farms, the potential pork production can reach 56.1 million tons in China, which is slightly lower than demand. Due to the impact of the ASF epidemic, the food consumed by pigs has been reduced by 34.7 million tons. However, with increasing pork productivity in the future, the self-sufficiency rate of grains may further decline. On the premise that the quality of people's life is not affected, the diversification of meat supply channels should be realized in an orderly and sustainable way, which might conductive to alleviate the pressure on food supply. This study provides a theoretical reference for the spatiotemporal layout of the swine industry and addresses the issue of food security in China under the influence of ASF and the COVID-19 outbreak.